A clinical trial into the drug helped patients cut the amount they consumed from 12.75 units a day to five units a day – a 61 per cent reduction. And patients who underwent counselling as well as taking the drug reduced their “heavy drinking days” from 23 days a month to nine days a month after undergoing the treatment for six months, researchers said.
Nalmefene is touted as having a longer half-life than naltrexone and less effect on the liver, per the first link.
While the study didn’t focus on people wanting to quit drinking, it seems this is an obvious use for it.
Sounds like a good addition to the toolbox. That said, per the first link, I do not know why it is not available in the US if it has some superiority to naltrexone.
Some interesting research funded by the National Institute on Alcohol Abuse and Alcoholism says yes.
Using brain scans, researchers found that people in recovery from alcoholism who showed hyperactivity in areas of the prefrontal cortex during a relaxing scenario were eight times as likely to relapse as those showing normal brain patterns or healthy controls.
The prefrontal brain plays a role in regulating emotion, the ability to suppress urges, and decision-making. Chronic drinking may damage regions involved in self-control, affecting the ability to regulate cravings and resist relapse.
It certainly sounds sensical. That said, it will be a long time before rehabs, let alone general medical clinics, are offering fMRI scans to people in early recovery to check this.
But, we can take away from this that the idea of “triggers” is a real concern, if long-term drinking has affected those regulatory abilities.
And, the difference is significant:
The investigators found that individuals in recovery who showed patterns of heightened activity in the prefrontal region during the relaxing situation were much more likely to experience cravings for alcohol and subsequent relapse. These patterns of craving-related activity increased the likelihood of early relapse by 8.5 times and relapse to heavy drinking by 8.7 times. Abnormally low activity during the stressful scenario was also linked to greater number of days drinking after relapse.
So, while we’re far from the point of offering fMRIs, it seems like the need is there.
Meanwhile, keeping that idea of “triggers” handy sounds good.
Candice Shelby, Ph.D., who gave a much-talked-about and much-appreciated presentation at the LifeRing Annual Meeting last June in Denver, has written an essay that I am very pleased to publish here for the first time. The essay is titled “Addicts are NOT Powerless — the Trick is Knowing Where the Power Is.” The essay explores the role of the mind in recovery from addiction and draws on Dr. Shelby’s studies in neurobiology and the nature of the mind.
Dr. Shelby’s piece focuses on the importance, in recovery, of the role played by the unconscious — but trainable — parts of our mental processes. Click here to see the article.
Dr. Shelby, an associate professor of Philosophy at the University of Colorado Denver campus, earned her M.A. and Ph.D. from Rice University. She served as Chair of the UC Philosophy Dept. for three years and has, in recent years, studied intensively the Philosophy of the Mind. She is currently at work on a book examining addiction from physical and psychological standpoints, focusing in particular on semantic elements in addiction and recovery.
When this newly redesigned Website was unveiled in June, there were some sections that didn’t make the initial transition. Since then, a LifeRing volunteer, Alceon, has done the necessary work to bring back the Keepers section and now has unveiled the new Toolbox section. Both are listed in the Categories menu along the right side of this page and can always be accessed using that link. Alceon’s work is greatly appreciated but she is not resting on her much-deserved laurels: she’ll be moving on to move the old website’s Poetry section next, followed by the Food & Beverages contents. LifeRing gains immensely from the efforts of members such as Alceon.